Oprah reveals struggle with 'shame' of weight-loss drugs and what happened when she quit

Even when sticking to her diet and exercise routines, the media mogul said she gained back 20 pounds after stopping the drug.

"It's going to be a lifetime thing," she shared. "I'm on high blood pressure medication, and if I go off the high blood pressure medication, my blood pressure is going to go up. The same thing is true now, I realize, with these medications. I've proven to myself [that] I need it."

"The combination of the medication and hiking every day and resistance training has given me the body that I had when I was running a marathon," she said. "So, I was 40 and feeling really good, but to be able to be 71 and feel that I am in the best shape of my life feels better than it did when I was 40."

In a new episode of "The Oprah Podcast" this week, Winfrey welcomed guest Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, to discuss GLP-1 weight-loss medications and her own personal journey. The two also co-authored the new book "Enough."

"One of the reasons I was reluctant to use them in the beginning, when I was trying to lose weight after my knee surgery, [is] because I also felt it's cheating, it's the easy way out," she said. "I've got to prove this one last time I could do it by myself. And I don't want people saying I took the easy way out."

"I think that that's one of the major issues that people who are now open to using the drugs are experiencing from their friends or colleagues, their families and also within themselves."

"Every time any comedian wanted to make fun or make a joke about it - they could make a joke about it. And I accepted it because I thought I deserved it," she said. "I accepted it. I was shamed by it and I received it, because I thought, 'Well, they're right.' Now I know they were so wrong."

"It feels like the punishment you deserve," Winfrey said.

"It's absolutely the opposite," Jastreboff responded. "And none of this is in our control. Somehow, in society, we think that how much we weigh is in our control. And it's not. Our brain is in control."

"All these years, I thought that thin people … just had more willpower, they ate better foods, they were able to stick to it longer, they never had a potato chip," she said.

Jastreboff agreed that while obesity is "not an addiction," the "food noise," or impulse to eat, uses the same pathways in the brain.

The discussion continued with guest Amy (last name withheld), a GLP-1 patient who lost 160 pounds in one year. She shared that in her experience, shaming by the public persists. Jastreboff responded that there is "no winning."

"You're shamed if you have obesity. You're shamed if you don't try to lose weight. You're shamed if you lose weight," the doctor said. "You're shamed if you use the medicines, if you don't use the medicines … there's literally no winning."

GLP-1 medications have been linked to several side effects, primarily gastrointestinal in nature. These commonly include nausea, vomiting, diarrhea, constipation and abdominal discomfort. Less frequently reported effects include fatigue, dizziness and reactions at the injection site. 

People interested in taking GLP-1s should consult a doctor about recommended dosage and potential risk factors.